Background: Immunosuppressive therapies are important parts of renal transplantation.Objective: To assess the present literature on the effectiveness of early introduction of mTOR inhibitors with or without calcineurin inhibitors (CNI) in renal transplant recipients in terms of renal functioning and graft survival.Methods: The current literature wa
Summary: The highly lethal brain cancer glioblastoma (GBM) poses a daunting challenge because the blood-brain barrier renders potentially druggable amplified or mutated oncoproteins relatively inaccessible.Here, we identify sphingomyelin phosphodiesterase 1 (SMPD1), an enzyme that regulates the conversion of sphingomyelin to ceramide, as an actiona
Recent archaeological excavations in the Portuguese region of Baixo Alentejo, carried out under the implementation of the irrigation project connected with the Alqueva Dam (EDIA), have brought to light important finds dated to the Cyclist Accessories - Clothing - Baselayer Southwestern Bronze Age.In this article, the first data of one of the larges
Abstract Background The Australian Commission on Safety and Quality in Health Care released a set of national standards which became a mandatory part of accreditation in 2013.Standard 9 focuses on the identification and treatment of deteriorating patients.The objective of the study was to identify changes in the characteristics and perceptions of r